Careers

Rain Therapeutics Inc. (“Rain”) is committed to empowering leaders with an entrepreneurial spirit that thrive in small team environments. Our hiring strategy requires recruiting top talent that seek an opportunity to tackle tasks independently, and develop creative solutions across the business. Our employees need to be passionate about developing therapies in cancer to save lives.

Rain is an equal opportunity employer. All qualified applicants will be considered without regard to age, race, color, sex, religion/creed, national origin, marital status, ancestry, citizenship, military, reservist or veteran status, pregnancy, sexual orientation or preference, gender identity, gender expression, physical or mental disability, genetic predisposition or carrier status, or any other category protected under applicable federal, state or local law.

If you are interested in joining the Rain team, please contact us at careers@rainthera.com

Open Positions:

Sr. Director of Drug Product Development and Manufacturing

Rain Therapeutics is committed to building a passionate team of core business leaders to implement our vision to identify and execute on the development of novel therapeutic avenues for the treatment of cancer.  The personality of Rain will always be focused on entrepreneurs with autonomy to build their respective teams in a flat organizational structure.

The Sr. Director, Drug Product Development and Manufacturing will lead drug product activities for all of Rain Therapeutics’ small molecule programs.  This individual will be responsible for the company’s CMC projects in terms of the development of formulations and processes of the drug products.  This individual will work independently to lead all aspects of drug product development activities in contract development and manufacturing organizations (CDMOs) from IND submission, clinical supply through Phase 3 and lead successful NDA submissions.  The individual will ensure that the content and quality of regulatory submissions meets the requirements in all markets specified by the regulatory requirements meeting needs of clinical or commercial teams.  Successful technology transfer of products to commercial manufacturing sites, process validation and support for the R&D responsibilities for pre-approval inspections will be ensured for all projects developed.  The successful candidate will interface with CMC and other Rain departments, ensure adequate staff are in place and may supervise direct reports to support CMC activities.  Develop, coach and lead associates to create high performing teams.  The individual will prepare drug product related project plans, timelines, budget projections, and assure development activities proceed in alignment with budget to achieve company goals. 

Rain is seeking an enthusiastic, driven, and diligent candidate who is a hands-on, detail-oriented individual who will partner well across all business functions and with corporate partners within the rapidly growing enterprise.  The successful candidate will have a stellar work ethic, the flexibility, and organizational skills to manage numerous and sometimes competing responsibilities of varying urgency within a fast-paced environment. 

The Vice President will report directly to the EVP of Technical Operations.

Key Requirements:

  • BS/MS degree in Chemistry, Pharmaceutics, Chemical Engineering, Pharmaceutical Chemistry, or related scientific disciplines with 15+ years of experience in the Pharmaceutical or Biotech industry with the focus on the small molecule drug product development and manufacturing 
  • Ph.D. with 10+ years of experience in the Pharmaceutical or Biotech industry with a focus on the small molecule drug product development and manufacturing 
  • Experience in writing CMC documents for regulatory submissions (IND/NDA/MAA)
  • A proven track record in developing and scaling up oral solid dosage forms including immediate, modified, and controlled-release formulations for tablets and capsules from pre-IND through Process Validation using the Quality by Design (QbD) concepts and design of experiments (DoE) 
  • Must have NDA preparation experience 

Position Description

  • Oversee contract development organizations (CDMOs) to lead development and optimization of drug product formulations to support the program from phase I clinical through commercial launch 
  • Review and approve master batch records, executed batch records, manufacturing deviations and investigations in conjunction with quality assurance
  • Provide on-site technical Man-In-Plant (MIP) support to oversee manufacturing activities 
  • Generate and/or review experimental plans and lead drug product development activities from research formulations, IND-enabling studies, preparation and optimization for registration and commercialization
  • Analyze and summarize complex data sets, including the use of appropriate statistical tools for the identification of CPPs and CQAs, development of drug product specifications and shelf-life estimates for drug product formulations
  • Generate and/or review Process Validation documentation, including Product Validation Master Plans, Statistical Product Sampling Plans, Cleaning Validation Plans, and Process Performance Qualification Protocols in conjunction with engineering, analytical and quality assurance representatives
  • Prepare technical reports in support of planned regulatory submissions including INDs and NDAs
  • Write, review, and approve CMC portions of study reports and manufacturing process documentation for compliance with cGMP and other appropriate regulations and guidelines
  • Assist in supply chain logistics for drug product manufacturing activities

Preferred Qualifications

  • Extensive experience in product development, clinical supply, and registration batch manufacturing for oral solid dosage and aseptic liquid or lyophilized infusion product development
  • Experience in the contract manufacturing environment with an in-depth knowledge of unit operations for the small molecule drug products including blending, granulation, encapsulation, compression, and tablet coating
  • Experience in sterile product development, including formulation, filling, lyophilization and associated container closure systems
  • Experience in formulation and process technologies by utilizing the enabling formulation approaches to enhance the bioavailability of the BCS class 2 compounds 

Qualities for Success

  • Ability to accurately forecast project budgets and timelines, and manage projects within budget 
  • Ability to effectively work independently in a team environment and demonstrate substantial experience with managing external CDMOs to meet the timelines within the approved budget 
  • Effectively work within the Development department and with cross-functional team leaders to achieve corporate and program goals 
  • Communicate project status and concerns to management and project leadership
  • Develop, mentor and lead associates across CMC and development functions
  • Contribute to project plans for delivering the CMC strategy and project objectives
  • Successful oral and written communication and interpersonal skills
  • Very strong presentation skills, including preparation of presentation materials in slide format
  • Ability to travel up to 30% of the time

Rain Therapeutics is an equal opportunity employer, and we’re proud of our ongoing efforts to foster diversity & inclusion in the workplace.  Individuals seeking employment at Rain are considered without regard to race, color, religion, national origin, age, sex, gender, gender identity, gender expression, sexual orientation, marital status, medical condition, ancestry, physical or mental disability, military or veteran status, or any other characteristic protected by applicable law.

Apply for This Position

Sr. Director of Process Chemistry and Drug Substance Manufacturing

Rain Therapeutics is committed to building a passionate team of core business leaders to implement our vision to identify and execute on the development of novel therapeutic avenues for the treatment of cancer.  The personality of Rain will always be focused on entrepreneurs with autonomy to build their respective teams in a flat organizational structure.

The Sr. Director, Drug Substance Development and Manufacturing to lead process chemistry for all of Rain Therapeutics’ small molecule programs.  This individual will be responsible for the company’s CMC projects in terms of the development of chemical routes and processes of chemical intermediates and drug substance.  This individual will work independently to lead all aspects of process chemistry and drug substance development activities in contract development and manufacturing organizations (CDMOs) from IND submission, clinical supply through Phase 3 and lead successful NDA submissions.  The individual will ensure that the content and quality of regulatory submissions meets the requirements in all markets specified by the regulatory requirements meeting needs of clinical or commercial teams.  Successful technology transfer of processes to commercial manufacturing sites, process validation and support for the R&D responsibilities for pre-approval inspections will be ensured for all projects developed.  The successful candidate will interface with CMC and other Rain departments, ensure adequate staff are in place and may supervise direct reports to support CMC activities.  Develop, coach and lead associates to create high performing teams.  The individual will prepare drug substance related project plans, timelines, budget projections, and assure development activities proceed in alignment with budget to achieve company goals. 

Rain is seeking an enthusiastic, driven, and diligent executive who is a hands-on, detail-oriented individual who will partner well across all business functions and with corporate partners within the rapidly growing enterprise.  The successful candidate will have a stellar work ethic, the flexibility, and organizational skills to manage numerous and sometimes competing responsibilities of varying urgency within a fast-paced environment. 

The Senior Director will report directly to the EVP of Technical Operations. 

Key Requirements:

  • Ph.D. in Organic Chemistry with 10+ years of experience in the Pharmaceutical or Biotech industry with a focus on the small molecule drug product development and manufacturing 
  • A proven track record developing and scaling up small molecules processes from pre-IND through Process Validation using the Quality by Design (QbD) concepts and design of experiments (DoE) 
  • Experience in writing CMC documents for regulatory submissions (IND/NDA/MAA) 
  • Experience leading small molecule process research and manufacturing activities from Phase 1 through Phase 3 projects 
  • Must have NDA preparation experience. 

Position Description

  • Oversee contract development organizations (CDMOs) to lead development and optimization of chemical intermediates and final drug substance processes to support the program from phase I clinical through commercial launch 
  • Review and approve master batch records, executed batch records, manufacturing deviations and investigations in conjunction with quality assurance 
  • Provide on-site technical Man-In-Plant (MIP) support to oversee manufacturing activities  
  • Generate and/or review experimental plans and lead drug substance development activities from route scouting, process optimization, engineering batches, IND-enabling studies, preparation and optimization for registration and commercialization 
  • Analyze and summarize complex data sets, including the use of appropriate statistical tools for the identification of CPPs and CQAs, development of drug substance specifications and shelf-life estimates for intermediates and drug substance  
  • Generate and/or review Process Validation documentation, including Product Validation Master Plans, Statistical Product Sampling Plans, Cleaning Validation Plans, and Process Performance Qualification Protocols in conjunction with engineering, analytical and quality assurance representatives 
  • Prepare technical reports in support of planned regulatory submissions including INDs and NDAs 
  • Write, review, and approve CMC portions of study reports and manufacturing process documentation for compliance with cGMP and other appropriate regulations and guidelines 
  • Assist in supply chain logistics for intermediates and drug substance manufacturing activities 

Preferred Qualifications

  • Experience working with small molecule process development particularly in greater that 50 kg scale chemical development, tech transfer and manufacturing of registration batches 
  • Strong knowledge of applied analytical methodology relating to small molecule in-process controls, drug substance release testing and stability assessment 
  • Ability to identify and mitigate potential regulatory and quality risks for the drug substance manufacture and subsequent resolution of compliance and quality issues; e.g. ICH guidelines, FDA and EMA/CHMP, and other international regulatory requirements  
  • Experience in the selection, evaluation and approval of new CDMOs and suppliers for drug substance development activities, including Tech. Transfer RFPs for commercial suppliers 

Qualities for Success

  • Ability to accurately forecast project budgets and timelines, and manage projects within budget 
  • Ability to effectively work independently in a team environment and demonstrate substantial experience with managing external CDMOs to meet the timelines within the approved budget 
  • Effectively work within the Development department and with cross-functional team leaders to achieve corporate and program goals 
  • Communicate project status and concerns to management and project leadership 
  • Develop, mentor and lead associates across CMC and development functions 
  • Contribute to project plans for delivering the CMC strategy and project objectives 
  • Successful oral and written communication and interpersonal skills 
  • Very strong presentation skills, including preparation of presentation materials in slide format 
  • Ability to travel up to 30% of the time 

Rain Therapeutics is an equal opportunity employer, and we’re proud of our ongoing efforts to foster diversity & inclusion in the workplace. Individuals seeking employment at Rain are considered without regard to race, color, religion, national origin, age, sex, gender, gender identity, gender expression, sexual orientation, marital status, medical condition, ancestry, physical or mental disability, military or veteran status, or any other characteristic protected by applicable law.

Apply for This Position

Senior Scientist / Principal Scientist, In vitro Pharmacology

Rain Therapeutics is committed to building a passionate team of core business leaders to execute on our vision to identify and execute on the development of novel therapeutic avenues for the treatment of cancer.  The personality of Rain will always be focused on entrepreneurs with autonomy to build their respective teams in a flat organizational structure.

The Sr Scientist / Principal Scientist will be a key contributor to the development and execution of ongoing drug discovery projects. You will achieve this by applying your technical expertise in cell and molecular biology to create and run biochemical and cellular assays, measuring the ability of novel anticancer agents to modulate specific DNA repair pathways and mechanisms. You will also work in multi-disciplinary collaborations with CROs and leading academics, involving a high level of teamwork. Appointment will be at either Senior Scientist or Principal Scientist level depending on experience.

Rain is seeking an enthusiastic, driven, skilled and detail-oriented scientist who will partner well within the rapidly growing enterprise.  The successful candidate will have a stellar work ethic, the flexibility and organizational skills to manage numerous and sometimes competing responsibilities of varying urgency within a fast-paced environment. 

The Senior Scientist/Principal Scientist will report to the VP, Biology and Non-Clinical Development.

Key Requirements:

  • Ph.D. in biological sciences and minimum of 5 years of relevant hands-on experience in DNA damage response pathways or discovery with oncology focus
  • Broad knowledge of cancer biology required, with expertise in synthetic lethality or the DNA damage repair field highly preferred. Experience working in the DNA damage response field will be a distinct advantage
  • Proven track record in biochemical & cell-based assay development and screening, ideally within an industrial drug discovery setting
  • Extensive experience in standard laboratory techniques, including hands-on experience with CRISPR, RNAi, reporter assays and small molecule inhibitor treatment of cancer cell lines

Position Description

  • Develop, validate, and execute biochemical and screening assays to identify and characterize drug candidates in our pipeline of DNA repair-modulating small molecules
  • Perform mechanism of action studies to better understand how our drug candidates are affecting DNA damage repair pathways and genomic stability
  • Key contributor to the discovery research team, with broad responsibility helping us make novel discoveries to advance our pipeline assets
  • Identification and validation of cancer indications and contexts dependent on our drug targets to assist the clinical development of our programs
  • Work closely with our multi-disciplinary team of scientists, and interact with external CRO partners to generate novel hypotheses and advance our scientific priorities
  • Maintain up to date knowledge of advancements in the field and new laboratory techniques and technologies
  • Organize and present experimental results at regular internal meetings
  • Maintain accurate, well-organized experimental records
  • Deep understanding of DNA damage response biology, DNA repair pathways and cancer cell biology is highly desirable

Preferred Qualifications:

  • Excellent technical cell and molecular biology skills (e.g. D-loop assays, homologous recombination specific assays, SPR, single strand annealing, flow cytometry, imaging, cell culture, viability assays, reporter assays, etc) and a proven ability to apply these skills to cell-based assay development and screening
  • Experience with NGS technologies is preferred, and familiarity with pathway analysis and bioinformatic data analysis is a plus
  • Experience of drug discovery is desirable
  • Experience working in an industrial setting will be a distinct advantage

Qualities for Success:

  • Detail-oriented, self-motivated team player, with the ability to work independently
  • Well organized and able to maintain detailed records of experimental work
  • Ability to communicate clearly and decisively in an open, timely manner
  • Ability to effectively work independently in a team environment
  • A sense of adventure and excitement to help build a successful company and work in a highly dynamic team environment
  • Experience working in a fast-paced startup
  • Presentation skills, including preparation of presentation materials in slide format

Rain Therapeutics is an equal opportunity employer, and we’re proud of our ongoing efforts to foster diversity & inclusion in the workplace. Individuals seeking employment at Rain are considered without regard to race, color, religion, national origin, age, sex, gender, gender identity, gender expression, sexual orientation, marital status, medical condition, ancestry, physical or mental disability, military or veteran status, or any other characteristic protected by applicable law.

Apply for This Position