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Presentations
November 21, 2022
Corporate Presentation - November 2022
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November 11, 2021
Research and Development Day Presentation - November 2021
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Milademetan
Posters & Presentations
CTOS 2022
Mrinal M. Gounder, Amy M. Weise, Prasanna Kumar, Ben Tao, Arnaud Lesegretain, Vijaya G. Tirunagaru, Feng Xu, Richard Bryce, David S. Hong
Sustained disease control with MDM2 inhibitor milademetan in patients with advanced dedifferentiated liposarcoma
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ENA 2022
Vijaya G. Tirunagaru, Kanchan Singh, Xinyu Pei, Robert C. Doebele
Combination of MDM2 inhibition with milademetan and MEK inhibition leads to improved anti-tumor activity in cancer models harboring wild-type TP53
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ASCO 2022
Vijaya G. Tirunagaru, Feng Xu, Trista Hinz, Lynn E. Heasley, Richard Bryce, Avanish Vellanki, Nora Ku, and Robert C. Doebele
Using CDKN2A loss in the context of wild-type TP53 to predict sensitivity for the MDM2 inhibitor milademetan
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ASCO 2022
Mrinal M. Gounder, Gary K. Schwartz, Robin L. Jones, Sant P. Chawla, Victoria S. Chua-Alcala, Silvia Stacchiotti, Andrew J. Wagner, Gregory M. Cote, Robert G. Maki, Hanna Kosela-Paterczyk, Dale R. Shepard, Naisargee Shah, Richard Bryce, Robert C. Doebele, Shreyaskumar Patel
MANTRA: A randomized, multicenter, phase 3 study of the MDM2 inhibitor milademetan (RAIN-32) versus trabectedin in patients with dedifferentiated liposarcoma
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ASCO 2022
Ecaterina E. Dumbrava, Glenn J. Hanna, Gregory M. Cote, Thomas Stinchcombe, Melissa Johnson, Christopher T. Chen, Siddhartha Devarakonda, Naisargee Shah, Feng Xu, Robert C. Doebele, Mrinal M. Gounder
MANTRA-2: A phase 2 study of the MDM2 inhibitor milademetan in patients with TP53 wild-type and MDM2-amplified advanced or metastatic solid tumors
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AACR 2022
Mrinal M. Gounder, Gary K. Schwartz, Robin L. Jones, Sant P. Chawla, Victoria S. Chua-Alcala, Silvia Stacchiotti, Andrew J. Wagner, Gregory M. Cote, Robert G. Maki, Hanna Kosela-Paterczyk, Dale R. Shepard, Naisargee Shah, Richard Bryce, Robert C. Doebele, Shreyaskumar Patel
MANTRA: A randomized, multicenter, phase 3 study of the MDM2 inhibitor milademetan (RAIN-32) versus trabectedin in patients with dedifferentiated liposarcoma
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AACR 2022
Ecaterina E. Dumbrava, Glenn J. Hanna, Gregory M. Cote, Thomas Stinchcombe, Melissa Johnson, Christopher T. Chen, Siddhartha Devarakonda, Naisargee Shah, Feng Xu, Robert C. Doebele, Mrinal M. Gounder
MANTRA-2: A phase 2 study of the MDM2 inhibitor milademetan in patients with TP53 wild-type and MDM2-amplified advanced or metastatic solid tumors
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AACR 2022
Vijaya G. Tirunagaru, Feng Xu and Robert C. Doebele
Exploration of MDM2 gene amplification, co-mutation status, and prognosis in solid tumors
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AACR-NCI-EORTC 2021
Vijaya G. Tirunagaru, PH.D.
MDM2gene amplification as a predictive biomarker for the MDM2 inhibitor milademetan
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AACR-NCI-EORTC 2021
Vijaya Tirunagaru, Ph.D.
The MDM2 inhibitor milademetan induces synthetic lethality in GATA3 mutant, ER positive breast cancer
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AACR-NCI-EORTC 2021
Varsha Ananthapadmanabhan, Ph.D.
Milademetan is a potent, murine double minute 2 (MDM2) inhibitor, highly active in TP53 wild-type (p53WT) Merkel cell carcinoma (MCC) cell lines
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IASLC 2021 World Conference on Lung Cancer
Lynn Heasley, Ph.D.
The MDM2/p53 axis is a therapeutic vulnerability in malignant pleural mesothelioma
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EORTC-NCI-AACR 2020
Mrinal M. Gounder
Milademetan (DS-3032b or RAIN-32), an Oral MDM2 Inhibitor, in Well-Differentiated/Dedifferentiated Liposarcoma: Results From a Phase 1 Study in Patients With Solid Tumors or Lymphomas
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ASH 2019
Courtney D. DiNardo
A Phase 1 Dose-Escalation Study of Milademetan in Combination With 5-Azacitidine (AZA) in Patients With Acute Myeloid Leukemia (AML) or High-Risk Myelodysplastic Syndrome (MDS)
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ASH 2019
Naval Daver
A Phase 1 Study of Milademetan in Combination With Quizartinib in Patients With Newly Diagnosed (ND) or Relapsed/Refractory (R/R) FLT3-ITD Acute Myeloid Leukemia (AML)
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ESMO 2019
Toshio Shimizu
A Phase 2 biomarker-driven study evaluating the clinical efficacy of MDM2 inhibitor, milademetan, in patients with intimal sarcoma, a disease with a high unmet need
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Rad52
posters & presentations
Targeting BRCA1- and BRCA2-deficient cells with RAD52 small molecule inhibitors
Nucleic Acids Res. 2016 May 19;44(9):4189-99
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Simultaneous Targeting of PARP1 and RAD52 Triggers Dual Synthetic Lethality in BRCA-Deficient Tumor Cells
Cell Rep. 2018 Jun 12;23(11):3127-3136.
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